CLDN3 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2946-20, A2946-100
Citations, Manuals and SDS Available upon request.
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat.
Synonyms: RVP1; HRVP1; C7orf1; CPE-R2; CPETR2; CLDN3
GeneID: 1365
Swiss-Prot: O15551
Reactivity: Human, Mouse
Calculated Molecular Weight: 23kDa
Observed Molecular Weight: 20kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 141-220 of human CLDN3 (NP_001297.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Tight Junctions, Cytoskeleton, Endocrine Metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: MCF7, HT-29, THP-1
Cellular Location: Cell Junction, Cell Membrane, Multi-pass Membrane Protein, tight Junction
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.