DNMT3B Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2899-20, A2899-100
Citations, Manuals and SDS Available upon request.
Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Synonyms: ICF; ICF1; FSHD4; M.HsaIIIB; DNMT3B
GeneID: 1789
Swiss-Prot: Q9UBC3
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 96kDa
Observed Molecular Weight: 110kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 345-475 of human DNMT3B (NP_008823.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:200 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Epigenetics Nuclear Signaling, Epigenetic writers and erasers of core Histones
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: U-251MG, HCT116, mouse testis, C6
Cellular Location: Nucleus
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.