EPOR Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2917-20, A2917-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
Synonyms: EPO-R; EPOR
GeneID: 2057
Swiss-Prot: P19235
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 55kDa
Observed Molecular Weight: 60kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR (NP_000112.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, G protein signaling, Small G proteins, Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, Stem Cells, Hematopoietic Progenitors, Cardiovascular, Angiogenesis, Heart, Hypertrophy
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse liver
Cellular Location: Cell Membrane, Secreted, Single-pass Type I Membrane Protein
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.