GAD67/GAD1 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2938-20, A2938-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
Synonyms: GAD; SCP; CPSQ1; DEE89; GAD67/GAD1
GeneID: 2571
Swiss-Prot: Q99259
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 67kDa
Observed Molecular Weight: 67kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GAD67/GAD67/GAD1 (NP_000808.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200 | IF/ICC: 1:50 - 1:200
Research Areas: Signal Transduction, Endocrine Metabolism, Amino acid metabolism, Immunology Inflammation, Neuroscience
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, Mouse lung
Cellular Location: Axon terminus, Cell Cortex, Cytoplasm, GABA-ergic Synapse, inhibitory Synapse, Plasma Membrane, preSynaptic active zone
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.