GRPR Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A2940-20, A2940-100
Citations, Manuals and SDS Available upon request.
Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
Synonyms: BB2; BB2R; BRS2; GRPR
GeneID: 2925
Swiss-Prot: P30550
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 43kDa
Observed Molecular Weight: 43kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 235-384 of human GRPR (NP_005305.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Signal Transduction, G protein signaling, G-Protein-Coupled Receptors (GPCR), Neuroscience
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: U-87MG, SGC-7901, A-549, MCF7, Mouse brain, Mouse pancreas, Rat brain
Cellular Location: Cell Membrane, Multi-pass Membrane Protein
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.