ACVRL1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9755-20, A9755-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
Synonyms: HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; ACVRL1
GeneID: 94
Swiss-Prot: P37023
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 56kDa
Observed Molecular Weight: 60kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 404-503 of human ACVRL1 (P37023).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:200
Research Areas: Cancer, Signal transduction, Kinase, Cell biology developmental biology, Growth factors, Endocrine metabolism, Amino acid metabolism, Cardiovascular, Angiogenesis
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, Mouse spleen, Mouse kidney, Rat heart
Cellular Location: Membrane, Single-pass Type I Membrane Protein
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.