MDH1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9673-20, A9673-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6.
Synonyms: KAR; MDHA; MOR2; DEE88; MDH-s; EIEE88; HEL-S-32; MGC:1375; MDH1
GeneID: 4190
Swiss-Prot: P40925
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 36kDa
Observed Molecular Weight: 36kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 235-334 of human MDH1 (P40925).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000
Research Areas: Cancer, Signal Transduction, Endocrine Metabolism, Carbohydrate metabolism
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, Jurkat, U-251MG, Mouse liver, Mouse brain, Rat kidney, Rat heart
Cellular Location: Cytoplasm
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.