STIM1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9764-20, A9764-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
Synonyms: GOK; TAM; TAM1; IMD10; STRMK; D11S4896E; STIM1
GeneID: 6786
Swiss-Prot: Q13586
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 77kDa
Observed Molecular Weight: 85kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 586-685 of human STIM1 (Q13586).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:100 - 1:500
Research Areas: Cancer, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism, Immunology Inflammation, B Cell Receptor Signaling Pathway, Neuroscience, Calcium Signaling
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: HeLa, BxPC-3, Mouse testis, Mouse brain, Rat testis
Cellular Location: Cortical Endoplasmic Reticulum, Endoplasmic Reticulum, Plasma Membrane, Plasma Membrane raft
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.