TIRAP Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9663-20, A9663-100
Citations, Manuals and SDS Available upon request.
Background: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Synonyms: Mal; wyatt; BACTS1; MyD88-2; TIRAP
GeneID: 114609
Swiss-Prot: P58753
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 24kDa
Observed Molecular Weight: 32kDa
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TIRAP (P58753).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IHC-P: 1:50 - 1:200
Research Areas: Kinase, Immunology Inflammation, Toll-like Receptor Signaling Pathway, Cell Intrinsic Innate Immunity Signaling Pathway, TLR Signaling, Cardiovascular
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: 293T, Hep G2, THP-1, Mouse brain, Rat spleen, Rat thymus
Cellular Location: Cell Membrane, Cytoplasm, Membrane
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.