Troponin I1/TnI1 Rabbit mAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9664-20, A9664-100
Citations, Manuals and SDS Available upon request.
Background: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Synonyms: TNN1; SSTNI; Troponin I1/TnI1
GeneID: 7135
Swiss-Prot: P19237
Reactivity: Human, Rat
Calculated Molecular Weight: 22kDa
Observed Molecular Weight: 22kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-187 of human Troponin I1/TnI1 (P19237).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: RD, Rat skeletal muscle
Cellular Location: Cytosol
Category: Monoclonal Antibodies
Citations, Manuals and SDS Available upon request.