FBLN5 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9961-20, A9961-100
Citations, Manuals and SDS Available upon request.
Background: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
Synonyms: EVEC; UP50; ADCL2; ARMD3; CMT1H; DANCE; ARCL1A; FIBL-5; HNARMD; FBLN5
GeneID: 10516
Swiss-Prot: Q9UBX5
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 50kDa
Observed Molecular Weight: 60kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 199-448 of human FBLN5 (NP_006320.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IF/ICC
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000 | IF/ICC: 1:50 - 1:100
Research Areas: Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Cytoskeleton, Extracellular Matrix, Cardiovascular, Cardiovascular diseases
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: A-431, Mouse lung, Rat lung
Cellular Location: Secreted, Extra Cellular Matrix, Extra Cellular Space
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.