RGS14 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A9962-20, A9962-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms: RGS14
GeneID: 10636
Swiss-Prot: O43566
Reactivity: Human, Mouse, Rat
Calculated Molecular Weight: 61kDa
Observed Molecular Weight: 54kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 230-510 of human RGS14 (NP_006471.2).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB, IHC-P
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:2000 | IHC-P: 1:50 - 1:200
Research Areas: Signal Transduction, G protein signaling, G-Protein-Coupled Receptors (GPCR), G-Protein-Coupled Receptors Signaling to MAPK Erk
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: SH-SY5Y, Mouse kidney
Cellular Location: Cell Junction, Cell Membrane, Cell Projection, Cytoplasm, Membrane, Nucleus, PML Body, Centrosome, Cytoskeleton, Dendrite, dendritic Spine, Microtubule Organizing Center, Postsynaptic Cell Membrane, Postsynaptic Density, Spindle, Spindle Pole, Synapse
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.