TGFB2 Rabbit pAb
Sizes: 20µl, 100µl
Catalogue Numbers: A25496-20, A25496-100
Citations, Manuals and SDS Available upon request.
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing.
Synonyms: LDS4; G-TSF; TGF-beta2
Swiss-Prot: P61812
Reactivity: Mouse
Calculated Molecular Weight: 48kDa
Observed Molecular Weight: 59kDa
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-414 of human TGFB2 (NP_003229.1).
Immunogen Species: Human
Host: Rabbit
Isotype: IgG
Purity: Affinity purification
Tested Applications: ELISA, WB
Storage Buffer: Store at -20℃. Avoid freeze / thaw cycles. | Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Recommended Dilutions: WB: 1:500 - 1:1000
Research Areas: Cancer, Invasion and Metastasis, Signal Transduction, Cell Biology Developmental Biology, Apoptosis, Growth factors, TGF-b-Smad Signaling Pathway, Wnt ??-Catenin Signaling Pathway, Endocrine Metabolism, Stem Cells, Cardiovascular, Angiogenesis
Modifications: Unmodified
Conjugate: Unconjugated
Positive Samples: Mouse uterus
Cellular Location: Secreted
Category: Polyclonal Antibodies
Citations, Manuals and SDS Available upon request.